Toxins

Experiments involving the deliberate formation of recombinant or synthetic nucleic acid molecules containing genes for the biosynthesis of toxin molecules lethal for vertebrates at an LD50 of less than 100 nanograms per kilogram of body weight (see Section III-B of the NIH Guidelines).

Major Actions

The deliberate transfer of a drug resistance trait to a microorganism when such resistance could compromise the ability to control the disease agent in humans, veterinary medicine, or agriculture (see Section III-A-1-a of the NIH Guidelines).

Lentiviral Containment

Use of CRISPR/Cas941

Human Gene Transfer

Biosafety Considerations for Contained Research Involving Gene Drive Modified Organisms

Guidelines for handling human material (Clinical BRF Guide)

Animal Experiments

• Animals in research

• Research with genetically modified animals

• Transgenic Animals and Use of Recombinant DNA in animals

• Guidance for Laboratory Work with Non-Human Primate (NHP)-derived Materials

Stem Cell Information

• NIH Guidelines for human stem cell research

• NIH Human Embryonic Stem Cell Registry

• CITI Training

Incident Reporting

• NIH FAQ Incident Reporting

• Template for Reporting Incidents

Dual Use of Research Concern Guidance (DURC)

• U.S. Government for Institutional Oversight of Life Sciences Dual Use Research of Concern

• TU Dual Use Research of Concern Guidance

• TU DURC Form

• DURC CITI Training Instructions

Effective May 2025:

• U.S. Government DURC & PEPP Implementation Guidance

• U.S. Government DURC & PEPP Policy for Oversight

Enrollment for required safety trainings